Mazindol inhibits appetite, so it is prescribed to improve the effectiveness of a low-calorie diet. There is a satiety center in the brain in the hypothalamus, which is directly affected by the main component of the drug. It acts on the adrenergic systems, which allows the effect of reducing the need for food.
Pharmacology and pharmacokinetics
The drug belongs to the amphetamine group, so it is an inhibitor of noradrenaline reuptake and inhibits dopamine and serotonin reuptake.
The maximum concentration of the drug in blood plasma is reached after 2-4 hours. The elimination half-life is about 33-35 hours. The effect of appetite reduction lasts up to 8-15 hours.
Peculiarities of application
Mazindol online can be purchased for the treatment of patients from 12 years old. Administration of the drug is started after consultation with a doctor and making an individual weight loss plan. The course of treatment begins with the prescription of 0.5 mg of the drug during the first 4-5 days.
The drug is taken during the first meal to increase satiety and reduce the desire to eat a few hours after breakfast.
After the start of treatment, the dose is increased, taking one or two Mazindol tablets. If the drug is taken twice a day, it is better to take one tablet at breakfast and one at lunch. To avoid negative effects on the body, you should not exceed the maximum daily dose, which is 3 tablets per day.
The course of treatment with Mazindol should not be longer than 12 weeks because usually this period is sufficient to obtain the desired result without compromising health. In addition, remember that after 8-10 weeks there may be an addiction to the drug, which reduces its effectiveness.
Do not take the drug with increased intraocular pressure – glaucoma.
Renal, hepatic and heart failure are also in the list of contraindications.
The drug is not suitable for the treatment of patients with arrhythmia, increased excitability.
The drug should not be combined simultaneously with MAO inhibitors. Therefore, if you are taking any medicine, and you want to order Mazindol online, please talk to your doctor or our pharmacist.
This medicine of the amphetamine group should not be taken if the activity requires high concentration: driving vehicles and operating machinery.
The administration is contraindicated in patients with a history of drug, alcohol, and medicines addiction. Also, the drug should not be used to treat patients with abnormalities of the nervous system, and depressive states. The drug should be used with caution to treat patients with a history of cardiovascular disease or the acute phase of the course.
Mazindol: side effects
In a control group of patients who took the drug for 12 weeks, the following adverse reactions were detected in isolated cases:
- Dry mouth, nausea
- Sleep disturbance
- Frequent urination
- Increased sweating
- Increase in BP
If side effects occur after taking this medicine, the dose should be reduced or the medicine should be stopped completely. Side effects appear more often at the beginning of treatment and disappear over several weeks. Severe allergic reactions have been found in only one patient out of 60.
Mazindol vs. Phentermine
Both drugs belong to the amphetamines group, so they have similar effects. Phentermine, unlike Mazindol, is not recommended to be taken in the evening because of the risk of insomnia. Phentermine cannot be used to treat patients under the age of 16 years, and Mazindol can be taken by obese patients from 12 years old.
Mazindol is more convenient to take since it can be taken with food. Phentermine should be taken 1-2 hours before breakfast and lunch.
Mazindol does not cause euphoria in therapeutic doses. Such an effect may occur only when taking a large dose. Unlike Phentermine, it doesn’t cause a pronounced withdrawal syndrome during an abrupt stop of treatment.
Mazindol: Weight loss
The medication is used to lose weight and improve the general condition of patients with a body mass index over 30. It is also effective for patients with a body mass index of 27 and above and the risk of complications due to excess weight: diabetes, and high blood pressure. To lose weight in the short term and avoid addiction, you need to combine medication with a low-calorie diet, moderate regular physical activity.
Mazindol 1 mg
To get the desired effect, 2 mg per day is prescribed with a split of two doses if the patient is 40 kg or less overweight. If the patient is over 50 kg, then 4 mg/day is prescribed. In such a case, two 1 mg tablets may be taken twice.
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